It is used as an orally ingested drug to enhance the excretion of isotopes of cesium and thallium from the body by means of ion exchange: thallium ions are excreted into the intestine and reabsorbed mainly in the colon into blood to be excreted again into the intestinal tract while cesium is excreted into the intestinal tract in the bile to be reabsorbed into portal blood and transported to the liver to again be excreted via bile (enterohepatic circulation). In 1987, following Goiania accident in Brazil ( International Atomic Energy Agency, 1988), Prussian blue was used in the management of a large scale radiation calamity ( Faustino et al., 2008). The disaster at the Chernobyl nuclear reactor in 1986 led to further studies on the elimination of radioactive cesium. It was recommended in the treatment of thallium intoxication in the 1970s and it is now normally used. The use of Prussian blue against thallium poisoning and as a decorporation agent for 134cesium and 137cesium has been investigated since the 1960s.

Prussian blue is available as Radiogardase ® in USA and Antidotum Thallii-Heyl ® distributed by Heyl Chemisch-pharmazeutische Fabrik GmbH, Berlin, Germany. Here this term refers only to insoluble ferric hexacyanoferrate(II).

A number of different, even if chemically related compounds, are named Prussian blue.

It was probably synthesized for the first time by the paint maker Diesbach in Berlin in 1704, and it was one of the first synthetic pigments. Guido Crisponi, Valeria Marina Nurchi, in Chelation Therapy in the Treatment of Metal Intoxication, 2016 2.2.6 Prussian Blueįerric hexacyanoferrate(II), known as Prussian blue, has the empirical formula Fe 4 3.

Antidote definition